New systems promise to inhibit the creation of 3D-printable firearms by identifying characteristic components, which could run into problems when they block the fabrication of any tube that is 9mm, 10mm, or any other diameter matching firearm ammunition. Just as with DRM, as long as self-created 3D printers are available, any software controls can be bypassed to allow the fabrication of protected designs. 

Researchers have been able to duplicate keys from photographs captured from up to 200 feet away, needing only blanks to create fully functional keys capable of bypassing traditional physical security controls in government, medical, and detention facilities.

As 3D-printable drugs, body tissues, and organs become available, ethical control of this new form of manufacturing will be difficult. Where we once were concerned with athletes doping their blood, we may someday have to find ways to identify custom body modifications that allow all manner of extreme physical feats.

Digitally fabricated viruses and other materials are entirely possible and will present a spectrum of difficulties in their application, liability, and legal controls.